Just as Mark Twain was the quintessential American author and captured the spirit, character and voice of a diverse nation, so too does the Hotel Mark Twain represent the spirit, character and diversity of the city that Mark Twain once called home.  From our plantation shutters to brass railed staircase, the Hotel Mark Twain is a nostalgic reflection of the San Francisco experience.  Located just blocks from Union Square and the Moscone Convention Center, the Hotel Mark Twain offers the ideal location for those traveling for business or pleasure.